In the context of increasingly severe environmental problems and economic transition, it has become a challenge for China at this stage to achieve a win-win situation of environmental regulation and employment. Based on the construction of mathematical model and panel data of 21 pollution industries in China from 2003 to 2011, this paper builds an empirical model for empirical analysis in order to analyze the impact of environmental regulation on the employment of pollution industry. The results show that, from the mathematical model, environmental regulation has a positive effect on the employment of the pollution industry. From the empirical results, environmental regulation and lagging environmental regulation indicators play a positive role in the employment of the whole pollution industry, and have a positive effect on the employment of the heavy pollution industries, and have little effect on the employment of the light pollution industries.