Innovation output is a direct reflection of enterprises’ innovation ability, and is also a source of enterprise value. Based on the data of A-share Chinese listed companies that disclosed patent licensing information from 2008 to 2017, this paper studies the impact of technical expertise of independent directors on innovation output. The results show that: Firstly, independent directors with technical background have a significantly positive impact on corporate innovation output, which is negatively regulated by economic policy uncertainty. Secondly,independent directors exert facilitation on innovation output by improving innovation investment. Thirdly, the multiple directorships of technical independent directors exert an inverted U-shaped curvilinear effect on innovation output. According to the above research conclusions, this paper suggests that enterprises should increase the introduction of independent directors with technical background and appropriately restrict their multiple directorships on other boards so as to make full use of the innovation-driven effects of technical independent directors and improve corporate innovation output.