Based on the relevant data of global clothing production and trade in 2017, this paper empirically examines the welfare effects of US tariffs on the industry level from a global perspective by using a computable partial equilibrium model. The simulation results show that: Firstly, the tariff imposed by US on Chinese clothing products has a significant trade disruption effect. However, due to the trade deflection effect, the export of Chinese clothing to EU, Japan and other third-party markets will increase. Secondly, in the context of globalization, due to the existence of trade diversion effect, the relief effect of tariffs on the American clothing industry is very limited. Thirdly, the loss of net social welfare in US is much higher than that in China due to the tariff imposed by the United States on Chinese clothing products. The research of this paper has certain reference significance for China to deal with the current Sino-US trade friction.