The popularization and deepening of global value chains have driven the shift in opening-up from the “instrument-based openness” dominated by GATT/WTO to the “institution-based openness” specific to policy adjustments and institutional reforms aimed at achieving open economy goals. Institution-based openness has propelled trade policy reforms from “border measures” to the deeper realm of “behind-the-border measures,” requiring the breaking of the limitations of border measures reforms and the deep integration of trade, industrial, technological, and corporate policies to serve the development of a high-level open economy. This necessitates the construction of a systematic thinking for opening-up strategies, fully leveraging the unique risk mitigation and uncertainty reduction functions of institution-based openness, effectively hedging against institutional frictions in globalization fluctuations, and significantly reducing cross-border transaction costs, thereby forming a high-level and resilient institutional supply and achieving a dynamic balance between the dividends of opening-up and national security. Consequently, it is essential to accurately extract relevant scientific issues, extensively carry out academic research on steadily expanding institution-based openness, attach importance to the in-depth exploration of the strategic significance of institution-based openness, and be aware of the various challenges faced by institution-based openness, in order to build a solid theoretical foundation and provide powerful policy tools for the shift from instrument based openness to institution based openness of trade policies.