Gini coefficient of urban scale, urban primacy, regional economic linkage strength and spatial compactness. Secondly, the optimized Super-SBM-Undesirable model is used to evaluate the sustainable development status of the Yangtze River Delta Economic Zone. Finally, a sustainable development correlation analysis model based on regional spatial structure is constructed. Based on the overall perspective of the Yangtze River Delta Economic Zone and the individual perspective of 11 provinces and cities, the relationship between the spatial structure of the Yangtze River Delta Economic Zone and sustainable development is analyzed.