Based on the panel data of 283 prefecture-level and above cities in China from 2006 to 2013，the spatial durbin model was used to empirically study the spatial effects of national audit on economic development quality.The results show that national audit can significantly improve the economic development quality of local cities，but it has negative spatial spillover effects on the surrounding cities；the impact of national audit on the quality of economic development in local and surrounding cities is a comprehensive reflection of the five action mechanisms，including kinetic energy conversion，structural upgrading，development efficiency，energy conservation and emission reduction，and achievement sharing，especially significantly on the kinetic energy conversion and energy saving and emission reduction.The influence of national audit on the quality of economic development of cities at different levels has obvious heterogeneity.The national audit of type II large cities and medium-sized cities can promote the quality of economic development in the region，but it obviously inhibits the improvement economic development quality in surrounding cities.However，the national audit of type I large cities or above and small cities has no significant impact on the quality of economic development in local and surrounding areas.The results show that strengthening the national audit function and promoting cross-regional collaborative audit are of great significance for promoting high-quality economic development.